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Primaderm signature active · Prebiotic

Aeonome™

The prebiotic that teaches your skin to protect itself.

Your skin is home to millions of friendly bacteria. Aeonome™ feeds them, so they can rebuild the barrier that keeps moisture in and irritation out.

Barrier supportSensitive skinAntioxidantFragrance-free formulas
Primaderm Biodefense Prebiotic Serum surrounded by lilac molecular shapes

In one minute

What it is

A prebiotic: food for the good bacteria that already live on your skin. Not a probiotic, so nothing living is added; your own microbiome does the work.

What it does

A well-fed microbiome makes the skin barrier stronger. Less water escapes, fewer irritants get in, and the skin's own antioxidant defence switches on.

Why it matters

Pollution, sun and air-conditioning unbalance the microbiome every day. That is when skin turns tight, dull or reactive. Aeonome™ helps it recover.

Illustration of the skin surface with friendly bacteria being fed by Aeonome
The skin surface, magnified: friendly bacteria (blue, green) live on top of the outer cells. Aeonome™ (Æ) is what they feed on.

The idea, simply

Think of your skin as a garden.

A healthy lawn keeps weeds out on its own. Your skin works the same way: a thick, diverse layer of friendly bacteria keeps unwanted microbes in check and tells the cells underneath to stay strong.

Most skincare adds things on top. Aeonome™ feeds the lawn instead, so the skin builds its own protection, from the inside of the surface out.

Feed the good bacteria, and the skin does the rest.

Diagram of the four barriers of the skin: microbial, physical, chemical and immune
Primaderm's barrier model: four layers working together as one shield.

A little science, made simple

Your skin has four layers of defence. Aeonome™ supports all four.

When the microbiome is balanced, each of the other layers gets stronger too.

MicrobialFriendly bacteria crowd out troublemakers
PhysicalCells knit tighter, so less water escapes
ChemicalSkin keeps its healthy, slightly acidic pH
ImmuneFewer over-reactions, so less visible redness

What the studies show

Measured on real skin, not just in theory.

−27%
Skin roughness
after 28 days of use
−23%
Free-radical stress
the oxidation that ages skin
4 / 4
Barrier layers supported
microbial, physical, chemical, immune

Ingredient studies as reported in Primaderm's technical documentation (in vivo and in vitro); not tests of the finished product. Cosmetic effect on the look and feel of the skin; individual results vary.

Who it's for

If your skin often feels tight, looks dull or reacts easily.

  • Sensitive or reactive skin that flushes with heat, cold or air-conditioning
  • Dehydrated skin that drinks up moisturiser but still feels dry by noon
  • City skin exposed to haze, traffic and long hours indoors
  • Skin recovering after peels, retinoids or a harsh routine
Woman holding a jar of Primaderm Biodefense Prebiotic Mask against her shoulder
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