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Primaderm signature active · Expression-line peptide

Acetyl Hexapeptide-8 (Argireline®)

The peptide that softens the lines your expressions leave behind.

Every smile and frown folds the skin in the same place, thousands of times a day. Acetyl Hexapeptide-8 is the best-known peptide for softening the look of those expression lines.

Expression linesForehead & frown linesCrow's feetSmoother texture
Lilac swirl of Xpert Expression cream texture

In one minute

What it is

A chain of six amino acids, one of the most studied cosmetic peptides in the world. Primaderm uses it at high concentrations, up to 15% in the Booster SOS.

What it does

It works right where expression lines form, helping the skin look smoother each time it relaxes after an expression. Existing lines look softer and shallower.

Why it matters

Expression lines are the first wrinkles most of us notice, often in our thirties. An active that works where they form, not just on the surface, is what makes the change visible.

Illustration of a nerve ending releasing signal molecules towards a muscle
Where expression lines begin: the point where the skin is folded by every smile and frown.

The idea, simply

Think of it as taking the tension out of a fold.

Your face still moves and your expressions stay yours. What changes is how the skin looks once the expression has passed: the fold has less hold on it, and over time it looks softer.

Over days and weeks the skin, no longer creased so deeply, starts to look smoother, first in the crow's feet, then in the forehead and between the brows.

Less tension in the fold, softer-looking lines.

3D surface scans of crow's feet before and after treatment3D scan · crow's feetLifting direction
3D skin-surface scans of the crow's-feet area: the method Primaderm's studies use to measure wrinkle depth, fold by fold.

A little science, made simple

Seen with a 3D scanner, not just a mirror.

Researchers measured the depth of wrinkles with a 3D scanner before and after treatment. Three results stand out.

Crow's feetWrinkle volume down within a week at just 2%
Deeper linesWrinkle depth reduced by roughly a quarter in a month at 10%
TextureSkin roughness lower after 28 days

What the studies show

What the studies measured.

−27%
Wrinkle depth
after 30 days, 10% around the eyes
−21%
Crow's-feet volume
after 7 days at 2%
−20%
Skin roughness
after 28 days at 5%

Ingredient studies as reported in Primaderm's technical documentation (in vivo and in vitro); not tests of the finished product. Cosmetic effect on the look and feel of the skin; individual results vary.

Who it's for

If you see lines that stay after the expression has gone.

  • Crow's feet that linger after you stop smiling
  • Horizontal forehead lines and the "11" between the brows
  • Anyone who wants a gentle, gradual route to smoother-looking skin
  • Very expressive faces, or lots of screen-squinting
Small swirl of Xpert Expression cream
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